In a comprehensive cross-sectional study examining 3,101 US counties, researchers identified significant geographic variations in how social and environmental determinants of health (SEDoH) influence cardio-kidney-metabolic (CKM) syndrome-related mortality. The study utilized geographically weighted models to analyze the impact of various SEDoH, finding that median household income, food insecurity, and high school completion rates were the most significantly associated factors with variations in mortality rates across different regions.

The findings highlight the complexity and the regional differences in the association between SEDoH and CKM-related mortality, suggesting that one-size-fits-all health policy solutions may not be effective. The detailed analysis reveals not only the disparities in mortality rates but also the differentials in the impact of factors like food insecurity, pollution levels, and educational attainment on health outcomes. These insights are crucial for policymakers and healthcare professionals aiming to develop targeted interventions that address the root causes of health disparities and enhance overall public health outcomes in diverse communities across the United States.

Reference: Vieira de Oliveira Salerno PR, Cotton A, Elgudin YE, et al. Social and Environmental Determinants of Health and Cardio-Kidney-Metabolic Syndrome–Related Mortality. JAMA Netw Open. 2024;7(9):e2435783. doi:10.1001/jamanetworkopen.2024.35783